Sounds like a health issue.

"'As Seth Rogen acknowledges, 'If ‘Pineapple Express’ '—a druggy comedy he starred in with James 'had been about two girls, they wouldn’t have made it. And if I were a woman I wouldn’t have a career.'”

~ T. Friend

"Funny Like a Guy" | The New Yorker

http://www.newyorker.com/magazine/2011/04/11/funny-like-a-guy